1.
Tetrahedron Lett
; 56(23): 3365-3367, 2015 Jun 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26028781
RESUMO
The direct, regioselective, and stereoselective arylation of activated alkynes with aryl iodides using a nickel catalyst and manganese reductant is described. The reaction conditions are mild (40 °C in MeOH, no acid or base) and an intermediate organomanganese reagent is unlikely. Functional groups tolerated include halides and pseudohalides, free and protected anilines, and a benzyl alcohol. Other activated alkynes including an amide and a ketone also reacted to form arylated products in good yields.